Navigating Pharmaceutical Development: Analytical Solutions from Late Discovery through Scale-up
TGA Part 1 - Theory and Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, and 5500 instruments. The course will cover:
- Theory of operation
- Instrumentation
- Experimental parameters
- Software operation
- Calibration
- Maintenance and Troubleshooting
- Applications
Request More Information
Revolutionary New Fusion Cell™
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Powerful TRIOS Software
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Modulated DSC®
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
RCS 120 Refrigerated Cooling System
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
High Throughput DSC Autosampler
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
New Microscope Accessory
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Revolutionary New Fusion Cell™
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Powerful TRIOS Software
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting for thermal analysis and rheology. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
High Throughput DSC Autosampler
It’s hard to believe we could improve on the most reliable DSC autosampler on the market, but we did! The new linear autosampler was designed to be even more rugged and simpler to use than ever before.
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting for thermal analysis and rheology. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting for thermal analysis and rheology. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting for thermal analysis and rheology. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting for thermal analysis and rheology. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting for thermal analysis and rheology. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
- Fusion Cell™ with patented technology provides unrivaled performance in baseline flatness, sensitivity, resolution, and reproducibility. Its superb technology enables detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity measurements.
- Enhanced Tzero heat flow technology for the X3 guarantees temperature and enthalpy accuracy simultaneously on all three samples
- High-end performance with three sample calorimeters provide unmatched flexibility from replicate testing for statistical analysis to validation/verification against a control sample for the ultimate in certainty
- Modulated DSC® (MDSC®) for the most efficient separation of complex thermal events.
- One-Touch-Away™ User Interface enhances usability and access to data on the instrument.
- Reliable linear autosampler with 54 programmable tray positions for worry-free 24/7 operation, flexible programming of experiments, and automated calibration and verification routines.
- Widest range of refrigerated cooling options eliminates liquid nitrogen expense and ensures uninterrupted sub-ambient operation during extended autosampler routines.
- Tzero Press and pans for fast, simple, and reproducible sample preparation.
- Powerful software that delivers an exceptional user experience in a combined package for instrument control, data analysis, and reporting. Features such as automated calibration routines and real-time test method editing provide unmatched flexibility, while One-Click analysis and custom reporting raise productivity to new levels.
- Commitment to quality backed by the industry’s ONLY five-year cell and furnace warranty for peace of mind.
| Instrument Features | |
|---|---|
| Fusion Cell™ | X3 DSC |
| MDSC |  |
| Enhanced Tzero Heat Flow | |
| User Replaceable Cell | |
| 54-Position Autosampler | |
| Dual Input Gas-Delivery Manifold | |
| Color App-Style Touch Screen | |
| Included |
|
Revolutionary New Fusion Cell™
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Powerful TRIOS Software
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Modulated DSC®
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
RCS 120 Refrigerated Cooling System
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
High Throughput DSC Autosampler
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
New Microscope Accessory
Revolutionary new Fusion Cell™ further improves the performance on which you’ve come to rely. Better sensitivity, resolution, repeatability and industry leading baseline performance, enable detection of the weakest thermal transitions and the most accurate enthalpy and specific heat capacity.
Refrigerated Cooling Systems (RCS)
Take advantage of the convenient Refrigerated Cooling Systems (RCS) for unattended DSC and MDSC® operation over broad temperature ranges. The new RCS 120 provides enhanced safety and is the only liquid nitrogen-free system capable of conducting experiments down to -120°C.
RCS Features and Benefits:
- One-, Two-, or Three-stage refrigeration systems that achieve temperature ranges down to -40 °C, -90 °C or -120 °C
- Sealed system eliminates the need for liquid nitrogen cooling
- Enables cycling, MDSC®, controlled, and ballistic cooling experiments
- Safe, convenient, and continuous cooling operation for your laboratory needs
Refrigerated Cooling Systems (RCS)
Take advantage of the convenient Refrigerated Cooling Systems (RCS) for unattended DSC and MDSC® operation over broad temperature ranges. The new RCS 120 provides enhanced safety and is the only liquid nitrogen-free system capable of conducting experiments down to -120°C.
RCS Features and Benefits:
- One-, Two-, or Three-stage refrigeration systems that achieve temperature ranges down to -40 °C, -90 °C or -120 °C
- Sealed system eliminates the need for liquid nitrogen cooling
- Enables cycling, MDSC®, controlled, and ballistic cooling experiments
- Safe, convenient, and continuous cooling operation for your laboratory needs
Refrigerated Cooling Systems (RCS)
Take advantage of the convenient Refrigerated Cooling Systems (RCS) for unattended DSC and MDSC® operation over broad temperature ranges. The new RCS 120 provides enhanced safety and is the only liquid nitrogen-free system capable of conducting experiments down to -120°C.
RCS Features and Benefits:
- One-, Two-, or Three-stage refrigeration systems that achieve temperature ranges down to -40 °C, -90 °C or -120 °C
- Sealed system eliminates the need for liquid nitrogen cooling
- Enables cycling, MDSC®, controlled, and ballistic cooling experiments
- Safe, convenient, and continuous cooling operation for your laboratory needs
Refrigerated Cooling Systems (RCS)
Take advantage of the convenient Refrigerated Cooling Systems (RCS) for unattended DSC and MDSC® operation over broad temperature ranges. The new RCS 120 provides enhanced safety and is the only liquid nitrogen-free system capable of conducting experiments down to -120°C.
RCS Features and Benefits:
- One-, Two-, or Three-stage refrigeration systems that achieve temperature ranges down to -40 °C, -90 °C or -120 °C
- Sealed system eliminates the need for liquid nitrogen cooling
- Enables cycling, MDSC®, controlled, and ballistic cooling experiments
- Safe, convenient, and continuous cooling operation for your laboratory needs
Refrigerated Cooling Systems (RCS)
Take advantage of the convenient Refrigerated Cooling Systems (RCS) for unattended DSC and MDSC® operation over broad temperature ranges. The new RCS 120 provides enhanced safety and is the only liquid nitrogen-free system capable of conducting experiments down to -120°C.
RCS Features and Benefits:
- One-, Two-, or Three-stage refrigeration systems that achieve temperature ranges down to -40 °C, -90 °C or -120 °C
- Sealed system eliminates the need for liquid nitrogen cooling
- Enables cycling, MDSC®, controlled, and ballistic cooling experiments
- Safe, convenient, and continuous cooling operation for your laboratory needs
TRIOS Software
Discover powerful TRIOS software that delivers exceptional user experience in a combined package for instrument control, data analysis and reporting. New features such as automated calibration routines, multiple calibration sets, real-time test method editing, and inter-laboratory data and test method sharing provide unmatched flexibility, while one-click analysis and custom reporting raise productivity to new levels.
TRIOS Features & Benefits:
- Control multiple instruments with a single PC and software package
- Overlay and compare results across techniques including DSC, TGA, DMA, SDT and rheometers.
- Unlimited licensing and free lifetime software upgrades.
- One-Click analysis for increased productivity.
- Automated custom report generation including: experimental details, data plots and tables, control charts and analysis results.
- Convenient data export to plain-text, CSV, XML, Excel®, Word®, PowerPoint®, and image formats.
- Optional TRIOS Guardian with electronic signatures for audit trail and data integrity.• Modulated DSC® (MDSC®) for the most efficient separation of complex thermal events.
Ease-of-Use
TRIOS software makes calibration of the entire line of Differential Scanning Calorimeters simple. Users can easily generate multiple calibration data sets under varying experimental conditions (e.g. different heating rates or gas selections) and seamlessly switch between them to match the experimental conditions used for sample testing. Real-time signals and the progress of running experiments is readily available, with the added capability of modifying a running method on the fly. TRIOS software offers a level of flexibility that is unmatched in the industry.
Ease-of-Use
TRIOS software makes calibration of the entire line of Differential Scanning Calorimeters simple. Users can easily generate multiple calibration data sets under varying experimental conditions (e.g. different heating rates or gas selections) and seamlessly switch between them to match the experimental conditions used for sample testing. Real-time signals and the progress of running experiments is readily available, with the added capability of modifying a running method on the fly. TRIOS software offers a level of flexibility that is unmatched in the industry.
Ease-of-Use
TRIOS software makes calibration of the entire line of Differential Scanning Calorimeters simple. Users can easily generate multiple calibration data sets under varying experimental conditions (e.g. different heating rates or gas selections) and seamlessly switch between them to match the experimental conditions used for sample testing. Real-time signals and the progress of running experiments is readily available, with the added capability of modifying a running method on the fly. TRIOS software offers a level of flexibility that is unmatched in the industry.
Ease-of-Use
TRIOS software makes calibration of the entire line of Differential Scanning Calorimeters simple. Users can easily generate multiple calibration data sets under varying experimental conditions (e.g. different heating rates or gas selections) and seamlessly switch between them to match the experimental conditions used for sample testing. Real-time signals and the progress of running experiments is readily available, with the added capability of modifying a running method on the fly. TRIOS software offers a level of flexibility that is unmatched in the industry.
Ease-of-Use
TRIOS software makes calibration of the entire line of Differential Scanning Calorimeters simple. Users can easily generate multiple calibration data sets under varying experimental conditions (e.g. different heating rates or gas selections) and seamlessly switch between them to match the experimental conditions used for sample testing. Real-time signals and the progress of running experiments is readily available, with the added capability of modifying a running method on the fly. TRIOS software offers a level of flexibility that is unmatched in the industry.
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
- Theory of operation
- Instrumentation
- Experimental parameters
- Software operation
- Calibration
- Maintenance & Troubleshooting
- Applications
TGA Part 2 - Applications
Tuesday, June 23 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
- Theory of operation
- Instrumentation
- Experimental parameters
- Software operation
- Calibration
- Maintenance & Troubleshooting
- Applications
Request More Information
Trade in your Q Series DSC system and SAVE 40% on a NEW Discovery DSC
The world’s finest line of Differential Scanning Calorimeters
Trade in your Q Series DSC system and SAVE 40% on a NEW Discovery DSC
The world’s finest line of Differential Scanning Calorimeters
Discovery DSC
- New FusionCell™ with patented technology for unrivaled performance
- Exclusive Tzero® heat flow technology for ultimate DSC performance
- Unmatched baseline stability that requires no subtractions
- New linear 54-position autosampler
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
TGA Part 1 - Theory & Instrumentation
Monday, June 22 at 1:00 pm EDT
This lecture-based course covers all our TGA instruments, but is mainly designed around the Discovery TGA 55, 550, & 5500 instruments. The course will cover:
Discovery DSC
- New FusionCell™ with patented technology for unrivaled baseline flatness, sensitivity, and resolution
- Exclusive Tzero® heat flow technology for ultimate DSC performance
- Unmatched baseline stability that requires no subtractions
- New linear 54-position autosampler
Discovery SDT
- Simultaneous DSC/TGA
- Advanced modes for heat capacity, kinetic studies, and better resolution
- Horizontal dual-beam design for superior heat flow and weight measurements
- New 30-position autosampler with programmable tray positions
Discovery TGA
- New ultrasensitive proprietary Tru-Mass™ thermobalance
- The most accurate real-time data
- Superior atmosphere control to meet the most demanding applications
- Rugged & reliable automation
Discovery DSC
- New FusionCell™ with patented technology for unrivaled baseline flatness, sensitivity, and resolution
- Exclusive Tzero® heat flow technology for ultimate DSC performance
- Unmatched baseline stability that requires no subtractions
- New linear 54-position autosampler
Discovery DSC
- New FusionCell™ with patented technology for unrivaled baseline flatness, sensitivity, and resolution
- Exclusive Tzero® heat flow technology for ultimate DSC performance
- Unmatched baseline stability that requires no subtractions
- New linear 54-position autosampler
Discovery DSC
- New FusionCell™ with patented technology for unrivaled baseline flatness, sensitivity, and resolution
- Exclusive Tzero® heat flow technology for ultimate DSC performance
- Unmatched baseline stability that requires no subtractions
- New linear 54-position autosampler
Agenda
|
9:15 am – 10:00 am |
Registration & Pastries |
|
10:00 am – 10:20 am |
Waters Materials Sciences Introduction |
|
10:20 am – 11:00 am |
Calorimetric Insights: Using ITC to Assess Drug-Target Interactions |
|
11:00 am – 11:40 am |
Weight Matters: Leveraging TGA and SA for Drug Candidate Selection |
|
11:40 am – 1:00 pm |
Lunch |
|
1:00 pm – 1:40 pm |
Thermal Insights: Applications of DSC in Drug Stability and Drug-Excipient Interactions |
|
1:40 pm – 2:20 pm |
Calorimetric Clues: Understanding Complex Systems with Isothermal Microcalorimetry |
|
2:20 pm – 2:35 pm |
Navigating Viscosity in Formulation and Process Development |
|
2:35 pm – 3:00 pm |
Systematic AQbD-Based Method Development for Small Molecule Analysis |
Meet the Speakers
 |
Samuel Redstone Applications Scientist Samuel Redstone, PhD, is an applications scientist at Waters Materials Sciences providing applications support to the Microcalorimetry and Thermal Analysis product lines. Key responsibilities include providing customer support, performing instrument demonstrations, and teaching training courses. Prior to joining TA Instruments in 2021, Sam earned a PhD in Chemistry from the University of Utah, where, under the guidance of Prof. Cynthia Burrows, he studied the link between oxidative DNA damage and repair, and the key role that oligonucleotide structure played in this process. |
 |
Michael Mathews Senior Manager of Regional Applications Michael Mathews, Ph.D., is the Senior Manager of Regional Applications for the Americas at Waters Materials Sciences, where he leads a cross‑functional scientific team supporting advanced materials and life‑science applications. With more than 20 years of experience spanning structural biology, calorimetry, assay development, and product commercialization, Dr. Mathews has played key roles translating complex analytical technologies into practical solutions for biotechnology R&D, manufacturing, and quality workflows. His previous leadership roles include Vice President of R&D at OmniLytics, where he guided the development of bacteriophage‑based products targeting human and agricultural pathogens. Dr. Mathews is a published scientist and frequent international presenter on molecular interactions, microcalorimetry, and biophysical analysis, and holds a Ph.D. in Biochemistry from the University of Utah. |
 |
Cody Kroft Sr. Technical Support Specialist |
Tuesday, October 20, 2026
9:15 am - 3:00 pm EDT
Location
Waters Corporation
12368 Hancock Street Carmel, IN 46032
Google Maps
Advancing small‑molecule therapeutics demands rigorous research, precise analytical methods, and thoughtful formulation strategies. This free one‑day seminar brings together scientists from across the pharmaceutical R&D and formulation landscape to explore the critical stages of small‑molecule development—from late discovery and candidate selection to process optimization and scale‑up.
Throughout the day, we will examine common scientific and operational challenges that arise along the development pathway and demonstrate how leading researchers leverage thermal analysis and biophysical characterization to overcome them. You’ll gain actionable insights into the tools, methodologies, and best practices that empower teams to make informed decisions, optimize formulation and stability, and accelerate the progression of promising candidates toward the clinic.
Featured Techniques and Applications:
- Isothermal Titration Calorimetry (ITC) for binding studies, lead optimization, and mechanistic insights
- Thermogravimetric Analysis (TGA) for compositional analysis, stability assessment, and thermal decomposition profiling
- Differential Scanning Calorimetry (DSC) for polymorph identification, purity analysis, and formulation screening
- Sorption Analysis (SA) for assessing hygroscopicity, stability, and surface area analysis
- Isothermal Microcalorimetry for detecting low‑level stability changes and early degradation events
- Rheology for understanding flow, deformation, and processing behavior in complex formulations
Who Should Attend?
This seminar is open to professionals involved in pharmaceutical research, development, and manufacturing. Whether you are just beginning to explore analytical tools or are a seasoned expert, you will leave with valuable insights. Attendance is completely free, and lunch will be provided. Seats are limited so register today to save your spot!
Register Now
Request More Information
* Some modules and OEM products are excluded. Trade in required to receive discount. Please contact your local TA representative for more details. Deals valid for systems purchased and delivered before September 18, 2020.