Accelerate Your Research with High-Throughput DSC: Introducing the TA Instruments™ Rapid Screening DSC

Thermal stability is a leading indicator of overall clinical success of biologic drug products, and DSC (differential scanning calorimetry) is a primary tool used to characterize the effect of the solution environment on protein stability. The TA Instruments RS-DSC (Rapid Screening-Differential Scanning Calorimeter) is geared towards the biopharmaceutical industry with low volume, high concentration samples and offers a new dimension in DSC technology by employing simultaneous sample measurements to allow for significantly improved throughput over traditional microcalorimetric methods.

This presentation illustrates the applications of short-term thermal stability for screening of buffers and protein sequence modifications in antibody drug product development and concentration effects on duplex formation for antisense oligonucleotides (ASO). New data on high concentration protein samples demonstrates concentration dependence on thermal stability resulting from changes in the solution environment differentially affecting stability as protein concentration increases. To rapidly uncover the effects of concentration dependence, the TA Instruments RS-DSC allows for direct analysis of formulation strength biologic drug products.

Watch this webinar to learn:

• Introduction to the TA Instruments RS-DSC and its advantages for high-throughput analysis in the biopharmaceutical industry
• Understanding the importance of thermal stability in biologic drug development
• How you can use RS-DSC to accelerate early-stage screening processes
• Specific application examples for the RS-DSC